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American Journal of Biological and Pharmaceutical Research

Volume 7, Issue 2, 2020
Mcmed International
American Journal of Biological and Pharmaceutical Research
Issn
2348 - 2176 (Print), 2348 - 2184 (Online)
Frequency
bi-annual
Email
editorajbpr@mcmed.us
Journal Home page
http://mcmed.us/journal/ajbpr
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Abstract
Title
FORMULATION AND EVALUATION OF PITAVASTATIN BY NANOSUSPENSION
Author
Umasankar K, Sunitha P*, Jayachandra Reddy P
Email
sunipandu98@gmail.com
keyword
Pitavastatin, PVP K30, SLS, Poloxamer 407.
Abstract
Oral Nanosuspension of Pitavastatin was prepared by Precipitation method using various polymers such as SLS, PVP-K30, Poloxamer 407. All the formulation were evaluated for entrapment efficieny, zeta potential, SEM analysis, invitro dissolution studies. All the prepared formulations were found to be having entrapment efficiency within acceptable limits in the range of 92-101% respectively. IR spectroscopic studies indicated that there are no drug-excepient interactions. When compared to other all the formulations F9 is the best formulation which showed 97.52% of drug released respectively with in 45 min and follows First order release kinetics.
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