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Acta Biomedica Scientia

Volume 6, Issue 3, 2019
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
DEVELOPMENT AND EVALUATION OF NANOSPONGES DRUG DELIVERY SYSTEM OF CARVEDILOL BY USING SOLVENT EVAPORATION METHOD
Author
Roopa K*, Praveen Kumar J, Umasankar K, Jayachandra Reddy P
Email
roopa20081996@gmail.com
keyword
- Carvedilol, Nanosponges, FTIR, SEM.
Abstract
The Aim of this work is to the development and evaluation of Nanosponges drug delivery system of Carvedilol by using solvent evaporation method. Carvedilol is a BCS classII drug, having an half life of 7 hours, which wasn’t suitable for maintaining constant plasma concentrations. So Carvedilol was formulated as a nanosponge formulation for effective drug release. FTIR spectroscopy analyses indicated the chemically stable, amorphous nature of the drug in these nanosponge. SEM photographs revealed the spherical nature of the nanosponge in all variations. The formulation F11 has better results than remaining formulations. F11 formulation shows entrapment efficiency 98.64%, drug release release 97.24 % in 12 hour, and follows zero order with supercase II transport mechanism.
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