American Journal of Oral Medicine and Radiology

EVALUATION OF EFFICACY OF TOPICAL APPLICATION OF 5% AMLEXANOX ORAL PASTE AND 0.1% TRIAMCINOLONE ACETONIDE ORO-MUCOSAL PASTE IN THE TREATMENT OF ORAL LICHEN PLANUS

Vidhya Kalanjiam & G.V.Murali Gopika Manoharan

vidhya.kalanjiam@gmail.com

Amlexanox, Oral Lichen Planus, Triamcinolone Acetonide, Topical steroids.

Aims: The aim of the present study was to evaluate the efficacy of topical application of 5% Amlexanox oral paste and 0.1% Triamcinolone Acetonide oro-mucosal paste in the treatment of Oral Lichen Planus. Objectives: The objectives were to assess the clinical symptoms ,burning sensation or pain, erythematous change ,to assess the response to the treatment of Oral Lichen Planus by assessing reduction in burning sensation or pain, erythematous areas and white striae with size of the lesion and to compare the overall treatment response of two drugs – 5% Amlexanox oral paste and 0.1% Triamcinolone Acetonide oro-mucosal paste. Materials and Methods: 60 patients with Oral Lichen Planus were included in the study. After histopathological confirmation, the selected patients were divided into two groups – group A and group B. Patients in group A received 5% Amlexanox Oral Paste (n=30) and patients group B received 0.1% Triamcinolone Acetonide Oro-mucosal Paste (n=30) and their responses to the treatment were recorded. Results: Both the groups were asymptomatic at the end of the treatment course. But the rate of reduction of clinical sign stage was better in group B compared to group A. Group A showed 60% reduction in the clinical sign stage were as the group B showed 98% reduction at the end of 3 months. Conclusion: Topical application of 0.1% Triamcinolone Acetonide is more effective than Topical application of 5% Amlexanox in the treatment of Oral Lichen Planus. However Amlexanox can be used effectively for reducing the pain/burning sensation and erythematous area, devoid of the usual adverse effects associated with the use topical steroids, in patients for whom topical steroids are contraindicated.