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Acta Biomedica Scientia

Volume 6, Issue 3, 2019
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
FORMULATION OF SUSTAINED RELEASE MATRIX TABLETS OF ISONIAZID BY USING DIFFERENT POLYMERS
Author
G. R. Vijayasankar, V. Muruganantham, M. Shankar
Email
shankarmanichellappa@gmail.com
keyword
Antitubercular, Isoniazid, Sustained release, Matrix system
Abstract
Sustained release technology is relatively new field and as a consequence, research in the field has been extremely fertile and has produced many discoveries. The matrix system is most often used for a drug-controlled release from a pharmaceutical dosage form. Isoniazid is an antitubercular, with half life of 1.5-4 hours and requires multiple daily doses to maintain adequate plasma concentration. The present study was aim to formulate the sustained release oral matrix tablet by using isoniazid as a model drug and see the effects of different polymers. Various formulations of sustained release tablets of isoniazid were developed using various polymers Guargum, Carbopol, Tragacanth Gum and PEG-6000, in different proportion and combinations. IR spectra studies revealed that the drug and polymers used were compatible. In further studies the tablets were evaluated for physical characterization, in vitro swelling behavior, in vitro release study and stability studies
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