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Acta Biomedica Scientia

Volume 4, Issue 3, 2017
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
ANTICONVULSANT ACTIVITY OF CARYOTA URENS LEAF EXTRACT AGAINST MAXIMAL ELECTROSHOCK INDUCED CONVULSION
Author
Saravana Balaji MD, Krishnaraj S, Latha M, Aathirai K and Anjana Yogesh
Email
sehejan@gmail.com
keyword
Caryota urens, Diazepam, Clonus seizure and Anticonvulsant
Abstract
This study was aimed to evaluate the anticonvulsant activity of ethanolic leaf extract of Caryota urens maximal electroshock induced convulsion in mice. Ethanol (70%) was used as solvent to extract the phytoconstituents from Caryota urens leaves. The anticonvulsant activity was evaluated by MES model using 200 and 400mg/kg of ethanolic leaf extract of Caryota urens. Onset and duration of clonus seizure was observed after administration of Caryota urens before exposing the animals to MES. Diazepam was used as reference control. Both the doses of Caryota urens significantly reduced the onset and duration of clonus seizure and the percentage protection was also enhanced. Form the result it was concluded that, ethanolic leaf extract of Caryota urens exhibited anticonvulsant activity in mice against MES induced convulsion.
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