Acta Biomedica Scientia

A PROSPECTIVE ANALYSIS OF DRUG USE PATTERN OF GENERALIZED ANESTHESIA IN A TERTIARY CARE HOSPITAL

Lokya Naik S and China Koteswara Rao Peta

lokya_naik2001@yahoo.com

Propofol, poly-pharmacy, General anesthesia, DUE, Clinical pharmacist

Introduction: Based on the aspects of convenience and safety general anesthetics being the most frequently used anesthetics in health care field, in the present study to analyse drug use pattern in a tertiary health care hospital. Drug utilization review has become a potential tool in the recent years in evaluating the health care systems. With increased marketing of new drugs day by day and different types of drug prescriptions and polypharmacy has grown concern on delayed adverse effects and cost effective analysis of drugs especially in tertiary health care hospitals. To improve the drug prescribing, decision making, administration and drug use DUE lays a key role by educating and providing better suggestions to the health care team. Materials and Methods: The present study is a prospective analysis of drug use pattern of general anesthetics in RVS multi-speciality Hospitals, Chittoor, Andhra Pradesh, India. The study was designed to carry out in all the departments of hospital which is approved for carrying out the study by the Institutional Ethics Committee (IEC). Results and Discussion: The study consisted of about 71 patients who were undergone for surgery under general anesthetized condition. Various surgical procedures that have undergone in the study hospital during the study period are Laproscopic cholecystectomy, Radical mastectomy, neurologic surgery and cardio vascular surgery to a number of 42, 11, 8, 4 patients respectively. Patients are pre-anesthetized by using various drugs like ranitidine, alprazolam, midazolam, ondansetron, fentanyl at their required doses based on the clinical conditions of the patients. the mean dose of ranitidine administered in the dosage form of tablet was 137.3 mg, the mean dose of tablet alprazolam administered orally included a dose of 0.51 mg, intravenous administration of midazolam at a mean dose of 1.12mg, ondansetron at a dose of 3.89 mg, fentanyl at a dose of 136.76 mcg were given to the patients. Conclusion: From the study it is theoretically seen that the selection of drug is rationale based on the clinical condition. The use of propofol is found to be the most frequently used drug of choice for many surgical procedures in RVS Multi-specialty Hospitals. Further analysis of drug use is required for merely analyzing the economic strategies of hospital stay. It is also noted that abdominal surgeries are of high in number in the tertiary care hospital were the study has been carried out