Acta Biomedica Scientia

PATHOLOGICAL INFLUENCE OF BODY MASS INDEX ON CHRONIC KIDNEY DISEASES

Vamsi Krishna B, Mohan Kumar G, Jyothi Brahmaiah

vamsibvnv@gmail.com

Obesity, creatinine clearance, ESRD, AMPK

In united states, the prevalence of overweight which refers to BMI between 25 to 29.9 and obesity which refers to BMI 30 and more are 66% of overall population approximately, thus, obesity has become a worldwide epidemic. In both men and women increase in obesity has occurred with significance of 23 to 30% between 1988 and 2000. Various factors for obesity were found to be with syndrome X, over industrialization, especially in adolescents and men in present scenario. In figure 1 the mechanism involved in obesity initiated metabolic syndrome leading to kidney problems is clearly established. It has been reported that presently about 1.1 million population irrespective of age and gender are represented with BMI 25.0 to 29.9 kg/m2 and obesity which refers to BMI $30 kg/m2 are the growing epidemic health issue worldwide. Metabolic syndrome is the syndrome for which obese people are at high incidence. With a increased abdominal waist circumference at a range of .40 inches in men; .35 inches in women, hypertriglyceridemia at a ranges of 150 mg/dL or greater, low serum high-density lipoprotein cholesterol at a ranges of 40 mg/dL in men and, 50 mg/dL in women and elevated blood pressure (BP) ranges between 130/85 mm Hg or greater are the three major factors that indicates metabolic syndrome which was defined by the National Cholesterol Education Program. From review of various study reports it is clear that the association of obesity with metabolic syndrome is clear but their association with kidney disease which may lead to ESRD is not predictably clear, though it is demonstrated in animal and human studies that obesity is a main cause for epidemic diseases world-wide. Thus, it can be concluded that further studies to analyse the relation between muscle loss and creatinine clearance and AMPK inhibition and renal disease to be evaluated