Acta Biomedica Scientia

STUDY ON PREVALENCE OF POLYPHARMACY AND DDI’S IN GENERAL MEDICINE WARD

M.Venkata Ramana Prasad, Lakshmi Kiranmayi A, Keerthi Kishore Nagalla

mvramanaprasad@Gmail.com

DDIs, Major drug interactions, Lethal conditions, General medicine

Introduction: Many therapeutic guidelines have come into act for making rational use of all the modern medicine available for different diseases. But, despite of that guideline, though prescribed on their basis, some of the drugs are known to cause side effects that are caused by drug interacting with the other drug within the biological medium of the patient resulting in various fatal clinical conditions. Aims and Objectives: To assess the pattern of drugs prescription in general medicine department by the physicians. To assess the drug utilization in general medicine department. To evaluate the number of DDIs accounted in the study department. Materials and Methods: The study was carried out for 4 months in the year of 2017 in the departments of male general medicine ward and female general medicine ward. The study is a cross-sectional study that is carried by collected the individual case sheets from the departments by daily visits to the male and female general medicine departments. Results and Discussion: The overall study was carried out about 450 patients among which total of 372 drug-drug interactions have been identified. Among these 372 DDIs the interactions have been scrutinized for assessing the major DDIs. Around 29 cases have been identified to be accounted with major DDIs in overall study population with a percentage of about 6.44% of the overall study population. Conclusion: From the study it is concluded that the percentage of major DDIs accounted with 6.44% of overall study population. And the remaining 76.22% of the study population presented with minor and moderate drug- drug interactions. Hydrocortisone/Levofloxacin initiated DDIs are of more in number with 10 cases of overall 450 cases of study population. Thus, regular assessment is required for making better guidelines for therapeutic approach decisions.