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Acta Biomedica Scientia

Volume 4, Issue 3, 2017
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
FORMULATION AND EVALUATION OF GLIMEPIRIDE SUSTAINED RELEASE MATRIX TABLETS
Author
V. Prudhvi raj, M. Sushma, S. Sreedhar, T. Adhinarayana reddy, A. Laxmi Devi, Susheedhar, M. Niranjan Babu
Email
prudhvirajpharma9@gmail.com
keyword
Glimepiride, Acacia, Carbopol, Matrix tablets.
Abstract
The objective of this study was to develop sustained release matrix tablets of Glimepiride by wet granulation method based on combination of natural (acacia) and synthetic (Carbopol) polymers. Glimepiride is an oral hypoglycaemic agent, which is commonly prescribed for the treatment of patients with type II Diabetes Mellitus. Therapy with Glimepiride is usually initiated with 1 to 2 mg. The pharmacokinetics and dosage schedule supports once daily sustained release formulations for Glimepiride for better control of blood glucose level to prevent hypoglycaemia, enhance clinical efficacy and patient compliance. In this project Glimepiride sustained release matrix tablets are formulated with variable concentrations of natural and synthetic polymers and has been evaluated for its weight variation, Hardness, Friability, Disintegration, stability studies, order of kinetics and Dissolution studies. The results shown that Glimepiride containing Carbopol in F6 formulation fulfills all the requirements of a sustained release tablet.
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