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European journal of molecular biology and biochemistry

Volume 6, Issue 1, 2019
Mcmed International
European journal of molecular biology and biochemistry
Issn
2348 - 2192 (Print), 2348 - 2206 (Online)
Frequency
bi-annual
Email
editorejmbb@mcmed.us
Journal Home page
http://mcmed.us/journal/ejmbb
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Abstract
Title
FETUIN-A INTERCONNECT THE INSULIN, INSULIN RESISTANCE WITH TYPE 2 DIABETES
Author
Shailja Sarawagi, Jusmita Dutta, Ashish Jain
Email
riyaraja21@gmail.com
keyword
Insulin, Insulin resistance, Fetuin-A
Abstract
Introduction: Type 2 diabetes is a major metabolic disorder due to loss of insulin sensitivity in target cells, results hyperglycemia. The most common clinical features associated with type 2 diabetes are polyuria, polydipsia, and polyphagia and weight loss. The other long term medical complications related with type 2 diabetes are retinopathy, neuropathy, foot ulcer, nephropathy, cardiovascular disease and hypertension. Insulin resistance is one of the most important causes of type 2 diabetes. Fetuin-A is a multifunctional protein which block the auto phosphorylation of beta subunit of insulin receptor and produces insulin resistance. This is the connecting link between insulin resistance and type 2 diabetes. Aim: The present study evaluate the interconnection of fetuin-A , insulin and insulin resistance in type 2 diabetes patients. Materials and Methods: Blood samples were collected from 88 subjects (44 type 2 diabetes and 44 healthy controls). Insulin, HOMA-IR (Homeostatic Model Assessment of Insulin Resistance) and Fetuin-A were determined using conventional methods. Results: Insulin, HOMA-IR and Fetuin-A were significantly higher in type 2 diabetes patients as compared to healthy controls with p=<0.001.Conclusion: Our results suggest that Fetuin-A inhibit insulin action by blocking the auto phosphorylation of beta subunit of insulin receptor in type 2 diabetes patients.
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