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American Journal of Pharmaceutical Sciences

Volume 2, Issue 1, 2016
Mcmed International
American Journal of Pharmaceutical Sciences
Issn
XXX-XXXX (Print), XXXX-XXXX (Online)
Frequency
bi-annual
Email
editorajps@mcmed.us
Journal Home page
http://mcmed.us/journal/ajps
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Abstract
Title
EVALUATION OF HYOLIPIPDEMIC ACTIVITY OF BETULA ALNOIDES BARK ON TRITON WR-1339 INDUCED HYPERLIPIDEMIA IN ALBINO RATS
Author
Dominic Amal Raj1, Malarvili T*2, Velavan S3
Email
malarsai96@gmail.com
keyword
Abstract
The objective of the study was to investigate the antihyperlipidemic effect of Betula alnoides bark in triton WR 1339 induced hyperlipidemia in rats. Triton WR 1339 (350mg kg-1, i.p.) injection significantly (p<0.001) increased total cholesterol, triglyceride, very low density lipoprotein (VLDL), Low density lipoprotein (LDL), phospholipids and decreased high density lipoprotein (HDL). Betula alnoides showed dose dependant decrease in the total cholesterol, triglyceride, very low density lipoprotein (VLDL), Low density lipoprotein (LDL) and phospholipids. Betula alnoides increased high density lipoprotein (HDL). Administration of triton alone increased coronary risk index, atherogenic index and LDL, Betula alnoides and atorvastatin treatment decrease both the indices. It is concluded that Betula alnoides reduces total cholesterol, triglyceride, very low density lipoprotein (VLDL), Low density lipoprotein (LDL), phospholipids, coronary risk index, atherosclerotic index and increased HDL in triton induced hyperlipidemia in rats.Key words: Triton WR-1339, Betula alnoides, Coronary risk index, Hyperlipidemia, Lipid profile.
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