Acta Biomedica Scientia

EVALUATION OF ANTICANCER ACTIVITY OF COLDENIA PROCUMBENS LINN IN 1, 2-DIMETHYL HYDRAZINE INDUCED COLON CANCER ON RAT MODEL

K.Ramachandran* and R.Venketnarayanan

rcrama911@gmail.com

:-DCP - Dichloromethane extract of Coldenia procumbens, ACF-Aberrant Crypt Foci DMH-1, 2-Dimethyl Hydrazine. :-DCP - Dichloromethane extract of Coldenia procumbens, ACF-Aberrant Crypt Foci DMH-1, 2-Dimethyl Hydrazine. DCP - Dichloromethane extract of Cold

Background: Cancer is one of the significant health issues in the developed and developing nations. Anticancer activity is to prevent or suppress or reverse the carcinogenic progression by natural and synthetic or biological and chemical agents. In this current world colon cancer is the most common cancer when compare with other types of cancer. Throughout the world 1.2 million patients are detected for colon cancer in every year. In United States colon cancer is the second major causes for the death of both men and women. Cancers in the large and small intestine are the leading contributors for cancer morbidity and mortality in the world. In India the rate of colon cancer incidence was low in the past, but recently the incidence was increasing 35000 patients are suffering from colon cancer out of 3.5 million cases of cancer. Worldwide cancers are the second cause of death in the 21st century. Though several synthetic agents have been used for the treatment of cancer, due to their toxicity still research is going on for investigating chemotherapeutic agents of plant extract. In this Colon cancer occupies third position it is the most common cancer among the other. The presented study was determined to elucidate the in vivo anticolon cancer activity of Coldenia procumbens. Materials and Methods: The anticolon cancer effect of Coldenia procumbens against 1,2- dimethylhydrazine (DMH) induced coloncancer in male wistar albino rats. Results: DCP (Dichloromethane extract of Coldenia procumbens) which is a plant extract, at a dose of 200 and 400 mg/kg is found to decrease aberrant crypt foci (ACF) significantly (P<0.001). When compared to disease control (DMH), the weight of individual organs and hematological parameters have been increased significantly (P<0.001), which indicates the weight gain. Similarly, the total cholesterol level which is a biochemical parameter has been seen to be decreased significantly (P<0.01). We concluded that based on the above results Dichloromethane extract of Coldenia procumbens it has shows potent anti cancer activity.