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Acta Biomedica Scientia

Volume 4, Issue 3, 2017
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
A STUDY OF THERAPEUTIC EFFICACY OF MICRO NEEDLING WITH TOPICAL 5-FLUOROURACIL SOLUTION IN MANAGEMENT OF LOCALISED STABLE VITILIGO
Author
Ankit Kumar Singrodia*, Rajesh Dutt Mehta , Bhikam Chand Ghiya, Prasoon Soni , Pooja Goswami, Aastha Chawla
Email
ankit.singrodia@gmail.com
keyword
Vitiligo, 5-fluorouracil, Microneedling, Repigmentaion.
Abstract
Background: Vitiligo affects 1% of the world’s population with a higher incidence in dark-skinned individuals. Many medical treatments have been attempted with partial success, but recent focus has been on surgical techniques. The aim of this study was to evaluate the therapeutic efficacy of microneedling combined with topical 5-fluorouracil solution. Methods: A total of 102 lesions in 50 patients with localized stable vitiligo were treated. Microneedling combined with topical 5-fluorouracil solution was used which is available in the form of solution in concentration of 50mg/ml. The procedure was repeated after every 15 days up to 6 months and the patients were followed up for total 9 months. Results: The patients response to treatment (repigmentation) was graded as G1 <25% repigmentation (Poor), G2 25%-50% repigmentation (Fair), G3 50%-75 %( Good), G4 >75 %( Excellent).Results at the end of study are out of 102 lesion in grade 1 is 6 (5.88%), grade 2 is 12 (11.76%), grade 3 is 26 (25.49%), grade 4 is 28 (27.45%).CONCLUSION: Microneedling combined with 5-fluorouracil is efficent and better treatment in localised stable vitiligo.
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