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American Journal of Biological and Pharmaceutical Research

Volume 11, Issue 1, 2024
Mcmed International
American Journal of Biological and Pharmaceutical Research
Issn
2348 - 2176 (Print), 2348 - 2184 (Online)
Frequency
bi-annual
Email
editorajbpr@mcmed.us
Journal Home page
http://mcmed.us/journal/ajbpr
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Abstract
Title
FORMULATION AND EVALUATION OF IBUPROFEN BUCCAL PATCHES USING DIFFERENT POLYMERS
Author
Radhika.C, Rineesa C.K, Ashly Merin George*
Email
Ashly Merin George
keyword
Buccal patch, Ibuprofen, Solvent casting technique, Folding endurance, Swelling index.
Abstract
The aim of the study is to formulate buccal patch to maintain the site specific concentration of ibuprofen thereby to reduce the cost of therapy and to improve patient compliance. Buccal patch thickness in between 0.11-0.13 mm was prepared by solvent casting technique. Physicochemical evaluations such as weight uniformity (8.68-8.78 mg) folding endurance (270 to 290 times), drug content (87.42- 92.60%), swelling index (13.2 to 27.5), surface pH of the films were determined. The patches were prepared using three different combinations: Chitosan-HPMC, Chitosan - Gelatin, Chitosan-PVA incorporating ibuprofen as the drug. From different polymer combinations ibuprofen incorporated chitosan gelatin combination show a sustain release upto a maximum of 93.16% in 8 hrs. The optimized formulation subjected to microbiological analysis for confirmation of activity against S.aureus. It can be concluded that the buccal patches can be helpful for effective management of oral hygiene with sustained and localized release of ibuprofen.
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