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American Journal of Biological and Pharmaceutical Research

Volume 7, Issue 2, 2020
Mcmed International
American Journal of Biological and Pharmaceutical Research
Issn
2348 - 2176 (Print), 2348 - 2184 (Online)
Frequency
bi-annual
Email
editorajbpr@mcmed.us
Journal Home page
http://mcmed.us/journal/ajbpr
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Abstract
Title
FORMULATION AND CHARACTERISATION OF FLOATING MICROSPHERES CONTAINING CINNARIZINE
Author
B. Nagamani*, J. Hindu Manognya, K. Naga Raju, B. Deepika, T. Regupathi, KNV. Rao, K. Rajeswar Dutt
Email
nagamanireddy25@gmail.com
keyword
Cinnarizine, Gelatin, HPMC-K 100, CaCO3
Abstract
The purpose of present work was to develop floating microspheres of Cinnarizine for sustained drug delivery. The microsphere was prepared by solvent evaporation and ionic gelation technique. From the results it seem that formulation F4 was found to be satisfactory in terms of excellent micromeritic properties, yield of microsphere incorporation efficiency 82.32±1.8 and highest in vitro drug release of 100.02% in a sustained manner with constant fashion over extended period of time for 12 hrs. It was observed that concentration drug and polymer (HPMC-K 100) 1:4 and 40mg of NaHCO3 and CaCO3 affected all the evaluation parameter significantly.
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