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American Journal of Biological and Pharmaceutical Research

Volume 7, Issue 2, 2020
Mcmed International
American Journal of Biological and Pharmaceutical Research
Issn
2348 - 2176 (Print), 2348 - 2184 (Online)
Frequency
bi-annual
Email
editorajbpr@mcmed.us
Journal Home page
http://mcmed.us/journal/ajbpr
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Abstract
Title
FORMULATION AND EVALUATION OF CELECOXIB EMULGEL FOR TOPICAL DELIVERY
Author
Meghna KS *, Salini C, Sadiya P, Sreethu KS, Thushara C
Email
meghna.k.suresh @gmail.com
keyword
Emulgel, Celecoxib, Gelling agents.
Abstract
The use of non-steroidal anti-inflammatory drugs is well recognized for regional inflammatory disorders such as muscle pain, osteoarthritis, and rheumatoid arthritis. Celecoxib, a specific COX2 inhibitor, is one of the most potent non-steroidal anti-inflammatory agents. It is an insoluble drug and has irritant effect effect on GIT lead to ulceration and bleeding. The formulation of the product may play a key role for penetration and absorption of the active ingredient. Several formulation approaches for cutaneous administration of NSAIDS have been employed. The pharmaceutical forms particularly used for dermal administration to achieve local effects are gels, creams, ointments and emulgels. In the present study the emulgel was used for NSAIDs topical application. The aim of this study was to overcoming these two problems through preparation of this drug as topical emulgel. Sodium alginate and carbopol were the two polymers used as gelling agents, the influence of type and concentration of them on the release of celecoxib was investigated.
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