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American Journal of Biological and Pharmaceutical Research

Volume 7, Issue 2, 2020
Mcmed International
American Journal of Biological and Pharmaceutical Research
Issn
2348 - 2176 (Print), 2348 - 2184 (Online)
Frequency
bi-annual
Email
editorajbpr@mcmed.us
Journal Home page
http://mcmed.us/journal/ajbpr
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Abstract
Title
DEVELOPMENT AND EVALUATION OF ALPRAZOLAM IMMEDIATE RELEASE AND PROPRANOLOL SUSTAINED RELEASE FORMULATION USING CAP IN CAP TECHNOLOGY
Author
Rina Parveen H* and Siva P
Email
rinaparveenh003@gmail.com
keyword
Cap in cap technology, Alprazolam, Propranolol, immediate release, sustained release.
Abstract
In the present research work, a novel cap-in-cap technology is used for the development of Alprazolam Immediate Release and Propranolol Sustained Release formulation. To the best of our knowledge very less in formulation is available on this type of formulations. The advantages of fast releasing liquid-filled-capsules and slow release microspheres-filled-capsules were combined to meet the optimized requirements of our drug delivery system. Propranolol sustained release microspheres were prepared by emulsion solvent evaporation method using ethyl cellulose as polymer and were filled into a smaller capsule. Alprazolam fast is releasing liquid was prepared by using a simple dilution method using olive oil as a medium. This fast releasing liquid and slow releasing microsphere-filled-capsule was further inserted into a bigger capsule body and closed with the cap by sealing. The various formulation batches were subjected to physicochemical studies, entrapment efficiency, drug content, in vitro drug release and stability studies. Interaction studies reveal that there was no interaction between drug and polymers employed in this study. The optimized capsule-in-a-capsule formulation, released 95.90% of Alprazolam at the end of 2 hours and 49.41 % of Propranolol at the end of 12h. The drug release profile of Propranolol microsphere fits well with Higuchi model followed by zero order, first order and Korsemeyer-Peppa’s model. Korsmeyer-Peppas model analysis indicated that the drug release followed non-Fickian transport mechanism.
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