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European journal of molecular biology and biochemistry

Volume 6, Issue 1, 2019
Mcmed International
European journal of molecular biology and biochemistry
Issn
2348 - 2192 (Print), 2348 - 2206 (Online)
Frequency
bi-annual
Email
editorejmbb@mcmed.us
Journal Home page
http://mcmed.us/journal/ejmbb
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Abstract
Title
SERUM URIC ACID AND FOETAL OUTCOME IN PREGNANCY INDUCED HYPERTENSION (PIH)
Author
Radhe Natung , Sangeeta Naorem , Davina Hijam , Yanglem Ajitkumar Singh , Oinam Prabita Devi , Konsam Photan Singh , Salam Rojen Singh , Victoria Laishram , Amuba Singh
Email
biochemistsangeeta2121@gmail.com
keyword
Pregnancy induced hypertension, uric acid, foetal outcome
Abstract
To estimate the serum uric acid levels in pregnancy induced hypertensive (PIH) patients and in normal pregnant women and also to establish a possible association between serum uric acid and foetal outcome in these patients. Case-control study conducted in Department of Biochemistry in collaboration with Department of Obstetrics &Gynaecology, Regional Institute of Medical Sciences (RIMS); Imphal, Manipur. Data collected from 100 pregnancy induced hypertensive patients and 100 normotensive pregnant women admitted in Antenatal ward, Department of Obstetrics & Gynaecology, RIMS Hospital between September 2014 to August 2016. The blood samples were collected and analyzed for serum uric acid level and foetal outcome of these participants were noted. The serum uric acid was significantly elevated in pregnancy induced hypertensive women compared to normal pregnant women (7.85 ± 2.7 mg/dl vs 3.20 ± 0.81 mg/dl, p<0.05). Higher serum uric acid level (>7mg/dl) was significantly associated with bad foetal outcome (p<0.001) and lower serum uric acid (<5mg/dl) with good foetal outcome (p<0.001). Wo men with PIH had a higher incidence of assisted deliveries compared to control group (25 vs 4). And blood pressure was not statistically associated with foetal outcome (p>0.05). Serum uric acid was elevated in pregnancy induced hypertensive patients and was significantly associated with foetal outcome.
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