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European Journal of Environmental Ecology

Volume 10, Issue 1, 2023
Mcmed International
European Journal of Environmental Ecology
Issn
XXX-XXXX (Print), 2393 - 9672 (Online)
Frequency
bi-annual
Email
editorejee@mcmed.us
Journal Home page
http://mcmed.us/about/ejee
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Abstract
Title
HEMATOLOGICAL, BIOCHEMICAL ALTERATIONS, AND CHANGES IN HISTOLOGICAL ARCHITECTURE OF SOME TISSUE OF MALE WISTAR RATS EXPOSED TO 2,4-D HERBICIDE
Author
Ujjwala S Deshmukh* and P M Ramteke
Email
ujjwaladeshmukh@rediffmail.com
keyword
Herbicides, 2, 4-D, Histology, Haematology, biochemical analysis, liver, kidney, Testis.
Abstract
The phenoxy herbicide 2,4-D (dimethyl-amine salt DMA) is widely used herbicide to control the growth of weeds and broadleaf plants because of its selective nature. Albino Wistar male rats were given daily oral dose of 25% of LD50 of the 2,4-D (12mg/kg/body weight) dissolved in tap water for 120 days. Haematological analysis shows significant increase in TLC particularly in Eosinophill with slight decrease in Monocyte, while no alterations were found in RBC count and haemoglobin %. Biochemical analysis show significant increase in urea, uric acid and creatinine level. The histological study shows alterations in architecture of liver, kidney and testis of rats. In treated rats, hepatic cell of liver appear degranulated, hepatic cord becomes disarrayed and hydropic degeneration of some hepatocytes was observed. Sections of kidney showed inflammatory changes in the glomeruli with increased cellularity, capillary hyperemia, exudation, hypertrophy, tubular degeneration and the glomerular membrane was slightly thickened. Interstitial nephritis and edema was also visible along with extensive vacuolization in renal tubules. The testis exhibited shrinkage of seminiferous tubules.
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