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American Journal of Biological and Pharmaceutical Research

Volume 7, Issue 2, 2020
Mcmed International
American Journal of Biological and Pharmaceutical Research
Issn
2348 - 2176 (Print), 2348 - 2184 (Online)
Frequency
bi-annual
Email
editorajbpr@mcmed.us
Journal Home page
http://mcmed.us/journal/ajbpr
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Abstract
Title
EVALUATION OF ANTI-RHEUMATIC POTENTIALS OF PREMNA TOMENTOSA WILLD ON CHRONIC IMMUNOLOGICAL COMPLETE FREUND’S ADJUVANT -INDUCED ARTHRITIS IN RATS
Author
S.M.Shaheedha* and K.Bhaskar Reddy
Email
mahigold81@gmail.com
keyword
Premna tomentosa Willd., Complete Freund’s Adjuvant, Arthritic model.
Abstract
Premna tomentosa Willd belongs to the family Verbenaceae. Premna tomentosa commonly called as Krishnapalai is a medicinal plant. Anti-inflammatory activities of the Premna tomentosa have been reported in acute inflammation, but there is lack of evidence regarding anti-inflammatory properties of this plant in chronic inflammation. Therefore the present research evaluated the anti-rheumatic potentials of Premna tomentosa Willd on chronic immunological Complete Freund’s Adjuvant (CFA)-induced arthritis in rats. Methanolic extract of the whole plant of Premna tomentosa Willd. (MEPT 200 & 400mg/kg body weight p.o) and standard drug (Diclofenac sodium, 100mg/kg) suspended in 1% v/v tween 80 was prepared and administered to CFA arthritic rats. One day before the complete freund’s adjuvant was injected and daily treatment continued for 21days. The CFA arthritic model was created by the injection of 0.5ml complete freund’s adjuvant into the synovial cavity of the right knee joint of hind leg of rats. Oral dosage of MEPT was found to be significantly decreasing the humoral immune response by inhibiting the acute inflammatory reaction by reducing vascular permeability or other inflammatory mediators. The secondary arthritis lesions were reported to presume that,due to delayed hypersensitivity reaction ., MEPT exerted a marked significant effect on this stage. Haematological parameters also showed a significant improvement from the arthritic condition. These observations suggest the potency of MEPT in therapy for rheumatoid arthritis.
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