International Journal of Endocrinology & Metabolism Research

STUDY ON THE ASSOCIATION BETWEEN HYPERURICEMIA & ALBUMINURIA IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Subir Chandra Swar*, Atanu Chakraborty, Mridul Kanti Das, Avas Chandra Roy, Kingshuk Bhattacharjee

kb21084@gmail.com

T2DM, hyperuricemia, albuminuria, kidney.

Hyperuricemia is an independent risk factor for kidney dysfunction in diabetic patients. Various findings suggest that uric acid is an inflammatory factor and may have a role in endothelial dysfunction and act as a mediator of diabetic nephropathy. On the other hand, albuminuria is considered as the predicator of early stages of diabetic nephropathy. We investigated the correlation between hyperuricemia and albuminuria in patients with type 2 diabetes mellitus (T2DM).This study evaluated the association between serum uric acid & urinary albumin to creatinine ratio (ACR) among T2DM patients and also explored the relation between normoalbuminuria (ACR <30ug/ mg), microalbuminuria (ACR between 30μg/mg & 299 μg/mg) & macro albuminuria (ACR ≥ 300ug/mg) with serum uric acid levels. In a hospital based observational (cross-sectional) study of 100 patients (47 men and 53 women) in the age group of 40-80 years with T2DM, serum uric acid and urinary albumin-creatinine ratio were determined. Other metabolic parameters including lipid profile, glycated hemoglobin (HbA1c), serum creatinine (Cr), glomerular-filtration rate (GFR), body mass index (BMI), blood pressure, fasting plasma glucose (FPG) were assessed as well. Mean serum uric acid levels for normoalbuminuric, microalbuminuric and macroalbuminuric patients were 4.64 ± 1.07 mg/dL, 6.38 ± 1.3 mg/dL, and 7.68 ± 1.0 mg/dL, respectively. In T2DM patients, hyperuricemia was significantly positively correlated with FPG, HbA1C, Cr, LDL-cholesterol & triglycerides in patients with T2DM (P <0.001). No significant correlation found between hyperuricemia and age, sex, weight, height, BMI, hypertension & HDL-cholesterol. Serum Uric Acid level correlated negatively with GFR. In patientswith T2DM serum uric acid level correlated positively (p<0.001) with urinary ACR. This study showed that hyperuricemia was associated with a greater probability of albuminuria in patients with T2DM.