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European journal of molecular biology and biochemistry

Volume 11, Issue 1, 2024
Mcmed International
European journal of molecular biology and biochemistry
Issn
2348 - 2192 (Print), 2348 - 2206 (Online)
Frequency
bi-annual
Email
editorejmbb@mcmed.us
Journal Home page
http://mcmed.us/journal/ejmbb
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Abstract
Title
STEM CELL TRANSPLANTATION IN HIV PATIENTS: AN EXCITING PROMISE FOR CURE?
Author
Matin Ahmad Khan, Shubhashish Sircar, Uma Shanker Singh, Ranjeet Kumar Sinha, Binod Kumar, A K Jha, Nirmal Kumar Drolia, Fatin Raza Khan, Shahzeb Ahmad Khan
Email
mak5962@hotmail.com
keyword
Stem-cell transplantation (SCT), HIV.
Abstract
Survival of patients with HIV infection has improved considerably since the introduction of highly active antiretroviral therapy (HAART) but current approaches in HIV Therapy do have limitations. HIV DNA persists as ‘integrated genome‘, so such ARVs (anti-retro virals) are unlikely to prove ‘curative’. These therapies require long term ‘adherence’ to remain effective, associated with long term toxicities, chronic inflammation, T-cell dysfunction, and are expensive & hard to be delivered on world basis since then. Naturally people have started conjecturing for some kind of cure /eradication. Stem-cell transplantation from an HLA-matched donor (allo SCT) has failed in previous times, but one report a 40-year-old man, with HIV-1 infection since 1995 having a relapse of acute myeloid leukemia (AML) first diagnosed in 2006,.who underwent allogeneic stem cell transplant (allo SCT) with a donor selected to be homozygous for CCR5-δ32.and remaining free from the disease ever, has generated considerable amount of excitement and hope among people for for PLHAs (people living with HIV/AIDS) , for some kind of cure, even in form of ‘a functional ‘one.
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