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European journal of molecular biology and biochemistry

Volume 6, Issue 1, 2019
Mcmed International
European journal of molecular biology and biochemistry
Issn
2348 - 2192 (Print), 2348 - 2206 (Online)
Frequency
bi-annual
Email
editorejmbb@mcmed.us
Journal Home page
http://mcmed.us/journal/ejmbb
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Abstract
Title
CORRELATION OF SEAG WITH PLEURAL FLUID PROTEIN THIOLS AS PARAMETER TO DIFFERENTIATE EXUDATES FROM TRANSUDATES
Author
Moin Sabeer*
Email
drmoinsabeer@yahoo.com
keyword
SEAG, Pleural Fluid, Protein, Thiols.
Abstract
Recently SEAG has been reported as good parameter with sensitivity and specificity of 95% and 100%. SEAG is thought to directly reflect the colloidal osmotic pressure. The main advantage of SEAG was reduction in number of patient with transudate receiving concurrent diuretic therapy being misclassified as exudates. Oxidative status of pleural fluid has been analyzed by taking pleural fluid malondialdehyde level (PMDA) as well as different antioxidant enzymes to differentiate transudates from exudates. A total of 56 patients of pleural effusion were taken with diverse etiology, and then venous blood sample and pleural fluid were collected from these patients after diagnosing clinically, radiologically and after thoracocentesis. The greater differential value was found with a combination of SEAG and pleural fluid protein thiols, which correctly classified 92.31% of transudates and 93.34% of exudates with sensitivity and specificity of 92.31% and 83.34% and 93.34% and 92.31% respectively.
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