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European journal of molecular biology and biochemistry

Volume 6, Issue 1, 2019
Mcmed International
European journal of molecular biology and biochemistry
Issn
2348 - 2192 (Print), 2348 - 2206 (Online)
Frequency
bi-annual
Email
editorejmbb@mcmed.us
Journal Home page
http://mcmed.us/journal/ejmbb
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Abstract
Title
IN-VIVO ANTIFUNGAL ACTIVITY OF ETHANOLIC EXTRACT OF PROPOLIS AGAINST ASPERGILLUS FLAVUS IN RATS
Author
Dhandapani R* and Buvanaratchagan A
Email
sehejan@gmail.com
keyword
Propolis, antifungal activity, Aspergillus flavus and excision wound.
Abstract
Propolis and its extracts have long been used for the prevention and treatment of a variety of diseases due to its antibacterial, antiviral, antifungal, antioxidant, anesthetizing, cytostatic, anti-inflammatory, and immune strengthening, hepatoprotective effect, etc. The present study was conducted to evaluate the in vivo antifungal activity of ethanolic extract of Propolis against Aspergillus flavus exposed excision wound in rats. Female Wistar rats were divided in to 3 groups of 6 animals each. Group I served control, group II served as reference control applied with Nystatin and group III topically applied with 5% Propolis ointment. Excision wound was induced and Aspergillus flavus was spread over the wound. After 14 days of topical application of test drugs, the percentage wound contraction and fungal hyphae were observed. 5% of Propolis ointment showed significant (P<0.001) wound contraction and absence of fungal hyphae on staining techniques. From the result it was concluded that, ethanolic extract of Propolis showed antifungal activity against Aspergillus flavus exposed excision wound in rats.
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