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Australian Journal of Pharmaceutical Research

Volume 2, Issue 1, 2015
Mcmed International
Australian Journal of Pharmaceutical Research
Issn
XXX-XXXX (Print), XXXX-XXXX (Online)
Frequency
bi-annual
Email
editorajpr@mcmed.us
Journal Home page
http://mcmed.us/journal/ajpr
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Abstract
Title
FORMULATION AND EVALUATION OF EXTENDED RELEASE ALGINATE BEADS OF CEFIXIME
Author
Brahmaiah Bonthagarala*, Sreekanth Nama , Suresh Nuthakki, Donthiboina Sudarshan
Email
brahmaiahmph@gmail.com
keyword
Abstract
The objective of the present study was to prepare and evaluate the alginate beads of Cefixime. Cefixime alginate beads were prepared by orifice- ionotropic gelation method using polymers such as HPMC (K 100 M), Carbopol 940P, Sodium CMC, Guar gum, Sodium Alginate, Ethyl Cellulose, Methyl Cellulose and Xanthan gum. Totally 15 different formulations of Cefixime alginate beads were prepared by using the above polymers. The alginate beads were characterized for drug content, entrapment efficiency, mucoadhesive property by in vitro wash-off test and in-vitro drug release. The formulation F10 was selected as an ideal formulation based on the in vitro release profile which shows an extended drug release of 97.11% upto 8 hours in phosphate buffer of pH 7.0. Surface morphology (SEM analysis) and drug-polymer interaction studies (FT-IR analysis) were performed only for the ideal formulation (F10). The alginate beads were smooth and elegant in appearance showed no visible cracks as confirmed by SEM and FT-IR studies indicated the lack of drug-polymer interactions in the ideal formulation (F10). The in vitro release data of all alginate beads formulations were plotted in various kinetic equations to understand the mechanisms and kinetics of drug release. The ideal formulation (F10) followed Higuchi kinetics and value of "n" is calculated to be 0.86 indicated that the drug release shows non-fickian diffusion. Key words: Cefixime, Carbopol 940P, HPMC (K 100 M), Orificeionotropic gelation method, Cefixime, Sodium Alginate, Sodium CMC, Alginate beads.
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