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Asian Pacific Journal of Nursing

Volume 10, Issue 2, 2023
Mcmed International
Asian Pacific Journal of Nursing
Issn
XXX-XXXX (Print), 2349 – 0683 (Online)
Frequency
bi-annual
Email
editorapjn@mcmed.us
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Abstract
Title
THE ROLE OF GONGRONEMA LATIFOLIUM IN ATTENUATION OF CHLOROQUINE INDUCED NEPHROTOXICITY AND HEPATOXICITY
Author
*1Nnodim Johnkennedy,1 Uduji Helen Ifeoma and 2Udujih Godwin Obinna
Email
johnkennedy23@yahoo.com
keyword
Chloroquine, Nephrotoxicity,Hepatoxicity, Gongronemalatifolium.
Abstract
The attenuated effect of Gongronemalatifoliumagainst chloroquine induced nephrotoxicity and hepatoxicity was investigated in wistar rats. Twenty wistar rats were divided into 4 groups of 5 rats per group. Animal in group one served as control while animal in group 2, 3 and 4 received single oral administration of chloroquine (970mg/kg body weight). However experimental group 3 and 4 were additionally treated with 250mg /kg and 500mg/kg body weight of leaf extract of Gongronemalatifoliumrespectively. The treatment lasted for 14days. The results obtained showed that the serum urea and creatinine significantly increased in group 2 than in group 1, but significantly reduced in group 3 and 4 when compared with group 2 (P<0.05). On the other hand, serum bilirubin, AST, ALT, and ALP levels were significantly increased in group 2, when compared with the control. However, the level of serum bilirubin, AST, ALT, and ALP levels dropped marginally in group 3 and 4. This observation probably implies that the leaf extract of Gongronemalatifoliumattenuated the nephrotoxicity and hepatoxicity induced by chloroquine. Hence the use Gongronemalatifolium could be helpful to patients with liver and kidney derangement.
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