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Acta Biomedica Scientia

Volume 4, Issue 3, 2017
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
FOLATE ANCHORED SAQUINAVIR ENTRAPPED PLGA NANOPARTICLES: STABILITY STUDY
Author
Ruchi Singh*, Smita Banerjee, and N. K. Jain
Email
ruchi1084@gmail.com
keyword
Nanoparticles, preformulation, stability, polylactide co-glycolide.
Abstract
Polymers are the most commonly explored materials for constructing nanoparticle-based drug carriers. Polymeric nanoparticles can be easily manipulated without the loss of their physical, chemical and biological properties. Freeze-drying of nanoparticles has been considered as a good technique to improve the long-term stability. In this study, we have described stability study of formulations relative to pure drug and stability analysis at different storage conditions.Our main aim in the present investigation was to confirm drug Saquinavir (SQV), polymer Polylactide co-glycolide (PLGA), ligand Folic acid (FA) characteristics and determine stability of Saquinavir (SQV), polymer (PLGA) and synthesized PEGylated PLGA NPs & SQV-loaded FA anchored PEGylated PLGA NPs for tumor targeting.Results: The drug is stable at normal storage medium condition and targeted nanoparticles were found to be most stable at the refrigerated conditions of storage. The developed formulation can be successfully used as potential delivery vehicle for delivery of SQV.
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