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American Journal of Biological and Pharmaceutical Research

Volume 7, Issue 2, 2020
Mcmed International
American Journal of Biological and Pharmaceutical Research
Issn
2348 - 2176 (Print), 2348 - 2184 (Online)
Frequency
bi-annual
Email
editorajbpr@mcmed.us
Journal Home page
http://mcmed.us/journal/ajbpr
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Abstract
Title
DESIGN AND EVALUATION OF PULSATILE DRUG DELIVERY SYSTEM CONTAINING PANTOPRAZOLE SODIUM
Author
Reshma Fathima K* and Sivakumar R
Email
fathimaresh786@gmail.com
keyword
Pulsatile drug delivery system, Lag time, Circadian rhythm, Pantoprazole sodium.
Abstract
The basic design of the pulsatile system consisted of rapid release of drug from core tablets after a lag time of 5hr. The objective of the present study was to develop and evaluate an oral pulsatile drug delivery system containing pantoprazole sodium to mimic the circadian rhythm of the peptic ulcer by releasing the drug with a distinct predetermined lag time of 5h. Totally six formulations were developed using different concentration of cross carmellose sodium and sodium starch glycolate. The prepared blend and core tablets were evaluated for FTIR, Micromeritics study, hardness, friability, weight variation, drug content, disintegration time, and dissolution study. The best formulation was selected for Eudragit S 100 coating and evaluated for dissolution. The result of the study indicates that the drug was released after lag time of 5 hrs. And thus the dosage form can be taken at bed time. So the content was released in morning hours. i.e. the time of symptoms.
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