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European journal of molecular biology and biochemistry

Volume 6, Issue 1, 2019
Mcmed International
European journal of molecular biology and biochemistry
Issn
2348 - 2192 (Print), 2348 - 2206 (Online)
Frequency
bi-annual
Email
editorejmbb@mcmed.us
Journal Home page
http://mcmed.us/journal/ejmbb
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Abstract
Title
SALIVARY FLUID: A MOLECULAR TOOL
Author
Ravi Kumar Pujari1* and Vidya N2
Email
raveepujari@yahoo.com
keyword
Salivary Markers, Oral Cancer, mRNA, Cancer Diagnostics.
Abstract
The 90% of oral cancers are oral squamous cell carcinoma. This cancer, when found early, has an 80 to 90% survival rate. At the moment, a lack in national screening programs together with a lack of definitive and satisfactory biological markers for early oral cancer detection has resulted in late stage diagnosis of oral cancer. Analysis of salivary parameters such as salivary flow rate, pH, buffer capacity, lactobacillus, and yeast content, presence of IgG, IgM and anti-La autoantibodies and raised protein levels such as that of lactoferrin and cystatin C as has been proposed for the diagnosis of Sjogren’s syndrome. Concerning cancer diagnostics and follow up altered levels of certain mRNA molecules have been detected in saliva in oral cancer patients and of certain proteins in several cancers
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