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European journal of molecular biology and biochemistry

Volume 6, Issue 1, 2019
Mcmed International
European journal of molecular biology and biochemistry
Issn
2348 - 2192 (Print), 2348 - 2206 (Online)
Frequency
bi-annual
Email
editorejmbb@mcmed.us
Journal Home page
http://mcmed.us/journal/ejmbb
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Abstract
Title
SEDATIVE EFFECT OF LAWSONIA INERMIS ROOT EXTRACT ON PHENOBARBITONE INDUCED SLEEPING TIME IN MICE
Author
Sridhar VR, Jayakumar P, Arun Seetharaman, Jaikumar S*
Email
sengt@rediffmail.com
keyword
Lawsonia inermis, Chlorpromazine, Sedative, Phenobarbitone and Sleeping time.
Abstract
Lawsonia inermis is a glabrous shrub or small tree, cultivated for its leaves although stem bark, roots, flowers and seeds have also been used in traditional medicine. Traditionally almost all the parts of the plant were used in the various ailments of CNS. Current study was conducted to evaluate the sedative property of ethanolic root extract of Lawsonia inermis on phenobarbitone induced sleeping time in mice. Swiss albino mice were divided in to four groups of 6 animals each. Group I served as control, received vehicle (0.1% CMC) and group II, received Chlorpromazine (5mg/kg). Group III and IV were administered orally with 200 and 400mg/kg of ethanolic root extract of Lawsonia inermis respectively. After 30 minutes of test drug administration, Phenobarbitone sodium (40mg/kg) was administered intra-peritoneal to all groups of animals. The time between the loss and recovery of the righting reflex was taken as the sleeping time. The results showed that, Both the doses 200mg/kg (P<0.05) and 400mg/kg (P<0.01) of ethanolic root extract of Lawsonia inermis significantly increased the phenobarbitone induced sleeping time when compared to control group. From the results, it may conclude that, the ethanolic root extract of Lawsonia inermis produced sedative effect in mice.
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