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American Journal of Biological and Pharmaceutical Research

Volume 7, Issue 2, 2020
Mcmed International
American Journal of Biological and Pharmaceutical Research
Issn
2348 - 2176 (Print), 2348 - 2184 (Online)
Frequency
bi-annual
Email
editorajbpr@mcmed.us
Journal Home page
http://mcmed.us/journal/ajbpr
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Abstract
Title
PHYTOCHEMICAL PROFILING AND MOLECULAR DOCKING ANALYSIS OF Piper nigrum. L AGAINST ORNAMENTAL FISH DISEASES
Author
A.Zahira*, K.Tamilmani and R Rafi Mohamed
Email
master.maniji@gmail.com
keyword
Earthworm, Aeromonas hydrophila, aerolysin(aerA), Piper nigrum, bioactive compounds, Molecular docking.
Abstract
Aeromonas hydrophila is a one of the major fish bacterial pathogens in India, which is more abundant in water. It causes variety of diseases in Poecilia sphenops (Black molly) and Puntius tetrazona (Tiger barb) fishes. A. hydrophila possesses aer A genes which produced aerolysin toxin and that causes haemorrhagic septicaemia, infectious dropsy, tropical ulcerative disease and fin rot leading to heavy mortality in aquaculture farms. Therefore, in the present study aerolysin (aerA) gene act as virulent factor which was docked against bioactive compounds from P .nigrum. GC-MS analysis of P .nigrum showed 54 Bioactive compounds, among them Piperine showed high energy value -698.77 than other compounds through molecular docking. This research work suggests that Piperine from P .nigrum has promising and potent anti-bacterial activities against fish pathogen Aeromonas hydrophila.
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