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Australian Journal of Pharmaceutical Research

Volume 2, Issue 1, 2015
Mcmed International
Australian Journal of Pharmaceutical Research
Issn
XXX-XXXX (Print), XXXX-XXXX (Online)
Frequency
bi-annual
Email
editorajpr@mcmed.us
Journal Home page
http://mcmed.us/journal/ajpr
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Abstract
Title
EVALUATION OF DIURETIC ACTIVITY OF AQUEOUS AND METHANOL EXTRACTS OF TINOSPORA SINENSIS IN RATS
Author
A. Srinivasa Rao1*, V. Girija Sastry2, B. Chandrakanth3, B. Durga Prasad1, J. Devilal1
Email
rajukasarla38@gmail.com
keyword
Abstract
In this present study, the diuretic activity was screened for methanol and aqueous extracts of Tinospora sinensis flowers. The animals were grouped into six of six groups. Test extracts were administered to experimental rats orally at doses of 150 and 300 mg/kg p.o suspended in carboxy methyl cellulose. The diuretic effect of the extracts was evaluated by measuring urine volume, sodium and potassium content, conductivity and pH. Urine volume was significantly increased by the two doses of aqueous and methanol extracts in comparison to control group. While the excretion of sodium was also increased by both extracts, potassium excretion was only increased by the aqueous extract at a dose of 300 mg/kg. There was no significant change in the conductivity and pH of urine after administration of the Tinospora sinensis extracts. The diuretic effect of the extracts was comparable to that of the reference standard Furosemide (20mg/kg, p.o). The present study provides a quantitative basis for explaining the folkloric use of Tinospora sinensis as a diuretic agent.Key words: Tinospora sinensis, Diuretic activity, Furosemide.
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