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Acta Biomedica Scientia

Volume 4, Issue 3, 2017
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
ACUTE AND SUB-ACUTE TOXICOLOGICAL EVALUATION OF THE SIDDHA SINGLE HERBAL FORMULATION SENGATHAARI ROOT BARK (SRB) DECOCTION IN RATS
Author
K. Vennila* and R. Pattarayan2
Email
drvennila2@gmail.com
keyword
Sengathaari, Capparis sepiaria, Siddha formulation, acute and sub-acute toxicity.
Abstract
Capparis sepiaria known as Sengathaari in Tamil is used in Siddha medicine for treating various skin diseases. In the present study acute and sub-acute toxicity studies of Sengathaari Root bark (SRB) decoction were carried out in rats using OECD guidelines 423 and 407.In acute toxicity study 2 groups of 3 female Wistar rats were given orally SRB decoction single dose of 10 ml/kg and observed for 14 days. The results indicated there were no clinical signs of toxicity and mortality at the dose level of 10 mg/kg per oral. In sub-acute toxicity study four groups of 10 Wistar rats (5male and 5female) were used. Group I (control) received normal distilled water, while rats in group II, III and IV were given daily oral dose of 1 ml/kg, 2.5 ml/kg and 4 ml/kg respectively for 28 days. The effect of SRB decoction on feed intake, water intake and body weight changes, biochemical, haematological and histological studies of vital organs namely heart, lungs, liver, kidney, testis and uterus were assessed. The results of the sub-acute toxicity study did not show evidence of any changes in body weight, food and water intake, hematological parameters, liver and kidney function tests when compared with the control animals. The vital organs of animals treated with SRB decoction for 28days did not show any histo pathological evidence of pathological lesions. From the results it is concluded that SRB decoction at the dose of 4ml/mg/kg per oral is safe for long-term treatment
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