Acta Biomedica Scientia

CYTOMORPHOLOGY OF GASTROINTESTINAL CANCERS OF SOUTH INDIAN COHORT - CASE STUDIES REPORT

K. Ramalingam1-4*, P. Indra Alias Muthu Meena4 and R. Karthik1

krmbiomed@gmail.com

Adeno carcinoma, Gastro-intestinal cancers, Cytomorphology, Ethinicity, Histological diagnosis.

The significant features of Adenocarcinomatous cancers of gastro colo-rectal regions include the presence of a cloud of peripheral glycoprotein viz., mucins, growth factors and expression of cell surface specific (CSSA) antigens. The appearance of a similar type of cancer in the different regions of gastro-intestinal- rectal continuum with differential cellular architecture in the present study infers the monotyphic cancer expansion driven by factors mentioned per se. The metabolic antero-posterior axis/gradient of the gastrointestinal tract might have favored the transits of the shed CSS antigens, growth factors and the mucin expression in succession. Understanding of this antero-posterior gradient of cancer cells phenotypic expression is of diagnostic value in tumor therapy of colorectal cancers since ablation of the malignant potions and chemotherapy would not suffice, in case of promoting factors/ antigens dispersion from proximal region to the distal region of the digestive continuum. The present study on the histopathological findings of the gastrointestinal cancers in the patients reveal that they have been subjected to numerous risk inducing factors before the manifestation. The epidemiology data reveal the following risk factors in these cancer patients namely, consanguineous marriage, tobacco chewing, smoking, pesticide usage, taking spicy pickle, alcohol, betel nut chewing, occupation, physical work nature, marital status, family history, eating habits, micro nutrients deficiency, co morbid conditions etc., Reducing the exposure to risk factors can prevent the development of gastro intestinal cancers. Cytomorphological tests and early assessment of cancer symptoms confer assured survival.