Acta Biomedica Scientia

EVALUATION OF CARDIAC TROPONIN I AND HS-CRP IN SUDANESE PATIENTS WITH ACUTE CORONARY SYNDROME

Mayadh Mahmoud Fadul1, Gad Allah Modawe2, AbdElkarim A. Abdrabo1*

abdrabokarim@hotmail.com

Acut Coronary Syndromes, Troponin I, High-Sensitivity C-Reactive Protein, ST-Elevation Myocardial Infraction, Unstable angina.

Cardiac biomarkers should be measured in all patients who present with chest discomfort consistent with acute coronary syndrome (ACS). Elevations of cardiac enzyme levels should be interpreted in the context of clinical and ECG findings. Cardiac troponins T and I are the preferred markers for myocardial injury as they have the highest sensitivities and specificities for the diagnosis of acute myocardial infarction. The objective of this study wasto estimate levels of cardiac troponin I and hs-CRP in patients with acute coronary syndrome. This study was cross section study, was conducted in Alshaab Hospital and Sudan cardiac Centre, Khartoum state. During September to November 2014. A total of 70 patients categorized according to ECG results to non-ST elevation myocardial infarction (NSTEMI) or ST myocardial infarction (STEMI) patients or unstable angina (UA). Serum troponin I was estimated using immune assay method, while serum HSCRP was estimated using immunofluorescence method. The (mean±SD)of serum hs-CRP and cTnI in patients respectively were (10.5±5.7,6.5±8.2). 35.7% of patients with UA show elevated hs-CRP (> 5 mg/L) while 6.7% of patients with STEMI and 50% show elevated levels of hs-CRP in patients with NSTEMI. cTnI seen elevated (>1.5 ng/ml) as follows: 3.6% in patients with UA, 96.6% in patients with STEMI, and 50% in patients with NSTEMI. This study concluded that, no available biomarker offers ideal diagnostic properties for ACS, such as early detection, high sensitivity and specificity, easy availability, and cost effectiveness. But cTnI and hs-CRP with ECG were with sufficient sensitivity and specificity in diagnosis of STEMI patients.