Acta Biomedica Scientia

CYTOKINES IN HIV-POSITIVE INDIVIDUALS WITH HYPERTRIGLYCERIDEMIA MAKING USE OF OMEGA-3

Camila Maria de Arruda1, Milena dos Santos Mantovani2, Renata Ferranti Estevam da Silva3, Paulo Câmara Marques Pereira4

camilamarianutricao@gmail.com

HIV, Omega-3, Hypertriglyceridemia, Cytokines

Currently AIDS is considered a chronic disease controlled with low morbidity and mortality. Antiretroviral therapy has been effective, but associated with serious adverse metabolic effects, including the epidemiological hyipertriglyceridemia. Trials demonstrate correlation between elevated triglyceride levels, changes in adipocytokines and coronary artery disease. The use of omega-3 fatty acid (w -3) has been advocated for hypertriglyceridemia, though without consensus. Objectives: To assess the effect of omega-3 fatty acid in patients with HIV on antiretroviral therapy (HAART) with triglyceride levels between 200 and 400 mg / dl, correlating with the levels of adipocytokines. 17 patients of both sexes with HIV / AIDS using antiretroviral drugs were studied in Specialized Outpatient Service of Infectious Domingos Alves Meira-UNESP, and divided into 2 groups (G 1 and G 2) on two occasions (baseline and after 4 months) all with the same nutritional guidance and physical activity. Omega-3 has been recommended in G1. In both groups were evaluated: anthropometric profile, erythrocyte, lipid and immune. Of the 17 studied, 7 were in Group 1, 43% were female, 46.1 ± 19.1 years old, and Group 2 consisted of 10 patients, 40% were female, 54.5 ± 25 4 years of age. Overweight occurred in both groups, with a tendency to not very significant improvement in Group 1 after 4 months, and in Group 2 there was a slight weight increase in M2. Waist circumference (WC), lean mass, body fat, body water, erythrocyte, and immunological profile showed no significant differences between groups. Total cholesterol and triglycerides showed a tendency to decrease in M2 in both groups, LDL increased slightly in Group 1 in M2. The adipocytokines showed trends to decrease. There was a significant correlation between the index values of body mass and CC. Although the results were not significant, the use of omega-3 associated with nutritional guidance and physical activity showed a trend of improvement in lipid and anthropometric levels, and cytokine profile. Accordingly, further studies with a larger number of patients, longer follow-up and larger doses of omega-3 should be made for the control and prevention of Cardiovascular Diseases.