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Acta Biomedica Scientia

Volume 4, Issue 3, 2017
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
MOUSE CEREBRAL CORTEX IS MORE VULNERABLE TO AGE RELATED DEPOSITION OF SENILE PLAQUES THAN THE HIPPOCAMPUS: A NEUROPATHOLOGICAL STUDY OF AMYLOID PLAQUES IN THE NORMAL PROCESS OF BRAIN AGING
Author
K.H. Pathan1, K.A. Gajare2 and A.A. Deshmukh1
Email
ashish_cellbio@rediffmail.com
keyword
Amyloid beta, Alzheimer’s disease, Amyloid precursor protein, Senile plaque.
Abstract
The amyloid β (Aβ) is a protein, deposited on the neuronal plasma membrane in the patients of Alzheimer’s disease (AD). It is considered as the hallmark of AD. It is generated due to the abnormal processing of amyloid precursor protein (APP). It exists in the isoforms like Aβ40 and Aβ42 that get deposited in the brain as senile plaques. Deposition of senile plaques leads to dementia. Enormous literature speculates the neuropathology of amyloidosis in AD. However, there are hardly any reports speculating the deposition of amyloid plaques in the normal process of aging. In the present investigation, we have studied the deposition of senile plaques by Congo red method in the cerebral cortex and hippocampus of Swiss albino mouse Mus musculus of 12, 18 and 24 months of age. As compared to 12 and 18 months, at 24 months of age the cortical and hippocampal region showed a highly significant increase in the deposition of senile plaques. Among the cerebral cortex and hippocampus, the cerebral cortex showed higher deposition of senile plaques. These results demonstrate the progressive deposition of senile plaques in the normal course of aging, i.e. in the absence of neurological disorder such as AD.
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