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Acta Biomedica Scientia

Volume 1, Issue 2, 2013
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
EVALUATION OF ANTIDEPRESSANT ACTIVITY OF METHANOLIC EXTRACT OF ANTIGONON LEPTOPUS
Author
Poonam Ranjan, Sushil Pratap, Dilip Kumar Tiwari, Kishu Tripathi*
Email
kishutripathi@rediffmail.com
keyword
Antigonon leptopus, Tail suspension test, Methanol, Antidepressant effect, Imipramine.
Abstract
Depression is an extremely common psychiatric condition, about which a variety of neurochemical theories exist and a number of synthetic antidepressant drugs are available in practice, however their effectiveness does not hold true with the entire range of population suffering from this disorder. Moreover the side effects and the drug interactions are major restrictions in its clinical utility. On the other hand, herbal medicines are widely used across the globe due to their wide applicability and therapeutic efficacy coupled with least side effects. The present study was conducted to evaluate antidepressant activity of Antigonon leptopus, popularly known as decorative flower. The experimental study was done by using tail suspension technique (TST) in albino rat. Methanolic extract (50, 100, 150, 200 and 250 mg/kg p.o.) of Antigonon leptopus leaves administered orally. After 30 min of administration, decreased immobility period significantly in a dose-dependent manner is occur and indicate significant antidepressant-like activity. The efficacies of the extracts were found to be comparable to imipramine (15mg/kg) in TST. There are preliminary phytochemical screening showed presence of alkaloids, flavonoids and triterpenoids in methanol extract of Antigonon leptopus. The present investigation validated traditional claims of the plant. It is finally concluded that antidepressant activity of Antigonon leptopus may be attributed to flavonoids.
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