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European journal of molecular biology and biochemistry

Volume 1, Issue 5, 2014
Mcmed International
European journal of molecular biology and biochemistry
Issn
2348 - 2192 (Print), 2348 - 2206 (Online)
Frequency
bi-annual
Email
editorejmbb@mcmed.us
Journal Home page
http://mcmed.us/journal/ejmbb
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Abstract
Title
EFFECTS OF TREATING OLD RATS WITH AN Agaricus blazei EXTRACT ON THE OXIDATIVE STATE OF THE LIVER
Author
Anacharis B. de Sá-Nakanishi, Andréia A. Soares, Jurandir Fernando Comar, Rosane M. Peralta and A. Bracht*
Email
adebracht@uol.com.br
keyword
Aging, Oxidative stress, Protection by Agaricus blazei.
Abstract
Increased oxidative stress during aging is a striking phenomenon in several tissues including the liver. For this reason there has been a constant search for drugs and natural products able to prevent or at least to mitigate this problem. In the present study we have conducted an investigation on the effects of an aqueous extract of Agaricus blazei, a medicinal mushroom, on the oxidative state of the liver of old rats (21 months). The extract was administered intragastrically during 21 days at doses of 200 mg/kg. The classical indicators for the oxidative state were measured as well as several antioxidant enzyme activities. The administration of the A. blazei extract was protective to the liver of old rats against oxidative stress by decreasing the lipid peroxidation levels and by increasing the protein reduced thiol groups content. These results are similar, though less pronounced, to those reported in a previous study with the brain of old rats. It remains to be demonstrated if these effects also occur in humans during aging. If confirmed, an extract of this mushroom could be incorporated into the diet of old people as a supplement able to stimulate the body defense against oxidative stress.
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