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European journal of molecular biology and biochemistry

Volume 1, Issue 5, 2014
Mcmed International
European journal of molecular biology and biochemistry
Issn
2348 - 2192 (Print), 2348 - 2206 (Online)
Frequency
bi-annual
Email
editorejmbb@mcmed.us
Journal Home page
http://mcmed.us/journal/ejmbb
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Abstract
Title
ANTICARCINOGENIC ACTIVITY OF PIPER NIGRUM EXTRACT AND ITS ACTIVE COMPONENT PIPERINE AGAINST 7, 12- DIMETHYLBENZ (A) ANTHRACENE INDUCED MOUSE SKIN CARCINOGENESIS
Author
Wasim Raja1*, Amit Dubey1, Lokendra Kumar Bandhe1 and Sonam Pandey2
Email
drwasimraja84@gmail.com
keyword
Chemopreventive, Papilloma, Tumor, Piperine, Black pepper, Skin carcinogenesis.
Abstract
Piper nigrum is famous as the spices king due to its pungent quality. Piper nigrum (P. nigrum) L. is a member of family Piperaceae. P. nigrum fruits are also used to produce white pepper and green pepper and are valued due the presence of piperine including its different isomers. Black pepper can be used for different purposes such as human dietaries, as medicine, as preservatives, as bio control agents, In the present investigation, the anticancer activity of Piperine and P. nigrum extract was evaluated using two stage in Swiss albino mice, induced by a single application of 7,12-dimethyadenz(a)anthrecene (104 μg/100 μl acetone) and one weeks later, promoted by repeated application of croton oil (1% in acetone/thrice a week) till the end of the experiment (16 weeks). The tumor incidence, tumor yield, tumor burdon and cumulative number of papillomas were found to be higher in the control (without P. nigrum treatment) as compared to experimental animal (P. nigrum treated). The difference in the values of the results of experimental group were statistically analyzed and found to be significant in comparison to the control group (p<0.05). In conclusion, the present study demonstrates the chemopreventive of P. nigrum on DMBA induced skin tumorigenesis in Swiss albino mice.
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