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European journal of molecular biology and biochemistry

Volume 1, Issue 5, 2014
Mcmed International
European journal of molecular biology and biochemistry
Issn
2348 - 2192 (Print), 2348 - 2206 (Online)
Frequency
bi-annual
Email
editorejmbb@mcmed.us
Journal Home page
http://mcmed.us/journal/ejmbb
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Abstract
Title
A CURRENT VIEW ON MICROSPONGE DRUG DELIVERY SYSTEM
Author
S. Kavya Lalitha, M. Shankar*, D. Likhitha, J. Dastagiri, M. Niranjan Babu
Email
shankarmanichellappa2014@gmail.com
keyword
Controlled release, Target specific drug delivery, Bone and tissue engineering
Abstract
The drug delivery technology landscape has become highly competitive and rapidly evolving. More and more developments in delivery systems are being integrated to optimize the efficacy and cost-effectiveness of the therapy In recent times, microsponge delivery system (MDS) has been successively addressed for the controlled release of drugs onto the epidermis. Microsponge is recent novel technique for control release and target specific drug delivery system. Drug loaded microsponge consist of microporous beads, typically 10-25 μm in diameter that possess a versatility to entrap wide range of active agents. Microsponge Systems are based on microscopic, polymer-based microspheres that can suspend or entrap a wide variety of substance. Microsponge technology offers entrapment of ingredients and is believed to contribute towards reduced side effects, improved stability, increased elegance, and enhanced formulation flexibility. In addition, numerous studies have confirmed that microsponge systems are non-irritating, non-allergenic and non-toxic. MDS technology is being used currently in cosmetics skin care, sunscreens. One of the best feature is it is self-sterilizing. it also expands its application in oral drug delivery, bone and tissue engineering. The versatile and unique properties of MDS made it ideal carrier of drugs with shorter half-lives and drugs which are suffering from first pass metabolism.
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