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Australian Journal of Pharmaceutical Research

Volume 2, Issue 1, 2015
Mcmed International
Australian Journal of Pharmaceutical Research
Issn
XXX-XXXX (Print), XXXX-XXXX (Online)
Frequency
bi-annual
Email
editorajpr@mcmed.us
Journal Home page
http://mcmed.us/journal/ajpr
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Abstract
Title
FORMULATION AND EVALUATION OF EXTENDED RELEASE TABLETS OF RANOLAZINE
Author
Ankith Kumar Reddy B, Sri vani*, Subhashis Debnath, Niranjan Babu M
Email
ankithpharmaline0002@gmail.com
keyword
Abstract
The present study was aimed to develop Ranolazine extended release tablets for the treatment of Angina, specifically reduces calcium overload in the ischemic myocyte through inhibition of the late sodium current (INa). Ranolazine extended release tablets enchance patient compliance and reduce adverse effects.A total of 9 formulations were developed using varying proportions of Hydroxy propyl methyl cellulose, carbomer as release retardant polymers by wet granulation technique. FT-IR studies revealed that there was no interaction between drug and polymers used.Before compression the granules were evaluated for precompression parameters such as bulk density, taped density, cars index, hausners ratio, angle of repose. After compression tablets were evaluated for appearance, weight variation, hardness, thickness, drug content, friability, in vitro release studies and stability studies.Key words: Hydroxymethylcellulose, Ranolazine, Carbomer.
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