Abstract
Title
ALDOSTERONE BASED OXIDATIVE STRESS APPRAISAL IN PREGNANT DOG
Author
Sudesh Agarwal, B.S.Saini, Mamta Saini, Satyendra, Ashish Joshi and Nalini Kataria*
Email
nalinikataria@rediffmail.com
keyword
Aldosterone, electrolytes, German Shepherd, oxidative stress, pregnant.
Abstract
The present endeavor was undertaken to appraise aldosterone based oxidative stress in pregnant dog. Sera were obtained to determine aldosterone, gamma glutamyl transferase (GGT) enzyme and electrolytes viz. Sodium, potassium, chloride, calcium, phosphorus and magnesium in healthy pregnant and non pregnant adult female German Shepherd dogs. Serum aldosterone levels were determined by radioimmunoassay. Results revealed significant (pï‚£0.05) increase in the values of serum aldosterone, GGT, sodium and chloride during pregnancy as compared to non pregnant state. Mean values of serum potassium, calcium, phosphorus and magnesium showed reverse trend and the values were significantly (pï‚£0.05) lower during pregnancy as compared to non pregnant state. Since serum GGT is an agreeably instituted indicator of oxidative stress, its raised levels denoted towards the expansion of oxidative stress in pregnant dogs. Greatest percent change was discerned in the mean value of serum GGT which was trailed by variation in serum aldosterone level. The present endeavor has tried to apprise the sorority of aldosterone with the oxidative stress as well as with electrolytes. It can be deduced that pregnancy produced the oxidative stress in the dogs. Interpretation of these variations will help to provide perceptive approach of various hidden mechanisms in the development of oxidative stress. Results clearly testified that apart from diseases, other stressors can also contribute in the development in oxidative stress and pregnancy is one of them. Canines must be supplemented with antioxidants regularly to protect them from the threats of oxidative stress particularly during pregnancy.The present endeavor was undertaken to appraise aldosterone based oxidative stress in pregnant dog. Sera were obtained to determine aldosterone, gamma glutamyl transferase (GGT) enzyme and electrolytes viz. Sodium, potassium, chloride, calcium, phosphorus and magnesium in healthy pregnant and non pregnant adult female German Shepherd dogs. Serum aldosterone levels were determined by radioimmunoassay. Results revealed significant (pï‚£0.05) increase in the values of serum aldosterone, GGT, sodium and chloride during pregnancy as compared to non pregnant state. Mean values of serum potassium, calcium, phosphorus and magnesium showed reverse trend and the values were significantly (pï‚£0.05) lower during pregnancy as compared to non pregnant state. Since serum GGT is an agreeably instituted indicator of oxidative stress, its raised levels denoted towards the expansion of oxidative stress in pregnant dogs. Greatest percent change was discerned in the mean value of serum GGT which was trailed by variation in serum aldosterone level. The present endeavor has tried to apprise the sorority of aldosterone with the oxidative stress as well as with electrolytes. It can be deduced that pregnancy produced the oxidative stress in the dogs. Interpretation of these variations will help to provide perceptive approach of various hidden mechanisms in the development of oxidative stress. Results clearly testified that apart from diseases, other stressors can also contribute in the development in oxidative stress and pregnancy is one of them. Canines must be supplemented with antioxidants regularly to protect them from the threats of oxidative stress particularly during pregnancy.
