American Journal of Biological and Pharmaceutical Research

HEPATOPROTECTIVE EFFECT OF INDIGENOUS FOENICULUM VULGARE IN ETHANOL INTOXICATED MALE AND FEMALE ALBINO RATS

Rajamanickam Vinodhini1*, Woyessa Adugna2, Tasew Geremew3, Nigussie Dereje4, Likisa Jimma5, Mosisa Biruk6

sivaniswetha@yahoo.com

Hepatotoxicity, Alkaline phosphatase Aspartate transaminase, Alanine transaminase, Phosphate buffer saline.

The liver performs many vital functions to eliminate toxins and harmful substances from the body. Hepatotoxic agents can directly interact with the liver through the formation of reactive radicals and consequently induce liver lesions with the progression of alcoholic liver disease. The aim of this study was to investigate the possible hepatoprotective effect of Foeniculum vulgare against ethanol induced hepatotoxicity in albino rats. The male and female rats with an average body weight (245 – 255g) were divided into ten groups as (Group 1 – Group 5) males and (Group 6 – Group 10) females in each group (n = 6) respectively. The rats were intoxicated with 30% of ethanol for 30 days. At the start of 31st day the rats (males: Group 4 – Group 5 and females: Group 9 – Group 10) were treated with 50 mg/kg and 1 g/kg of very fine powder of F. vulgare suspended in PBS. The males (Group 3) and Females (Group 8) were treated with suspension of Silymarin (50 mg/kg) for 30 days. At the end of experimental period all the animals were sacrificed to isolate the liver and blood samples. The biochemical markers such as alkaline phosphatase (ALP), alanine transaminase (ALT), aspartate transaminase (AST), total and direct bilirubin are increased in alcohol intoxicated groups. Supplemented with F. vulgare in the treatment period decreased and stabilized the concentration of all parameters in male and female rats. The reduction in total protein and albumin levels of alcohol intoxicated groups were significantly increased in F. vulgare treated male and female rats. The results of F. vulgare are in consistent with the Silymarin and control rats. This study confirmed the hepatoprotective effect of F. vulgare in alcohol intoxicated male and female albino rats.