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International Journal of Advances In Case Reports

Volume 11, Issue 1, 2024
Mcmed International
International Journal of Advances In Case Reports
Issn
XXX-XXXX (Print), 2349 - 8005 (Online)
Frequency
bi-annual
Email
editorijacr@mcmed.us
Journal Home page
http://mcmed.us/about/ijacr
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Abstract
Title
HYPOCOMPLEMENTEMIC URTICARIAL VASCULITIS SYNDROME IN AN ADOLESCENT
Author
Chen Volinsky, Rubi Haviv, Galit Pomeranz, Roxana Kleper, Tania Zehavi, Yosef Uziel, Avishalom Pomeranz*, Ze'ev Korzets
Email
avip2@clalit.org.il
keyword
hypocomplementemia, Urticarial vasculitis.
Abstract
Hypocomplementemic urticarial vasculitis syndrome (HUVS) is a rare autoimmune disease characterized by recurrent or persistent urticaria and low C1q, C2,C3 and C4 complement levels, along with multiorgan involvement. We describe a 17-year-old boy who presented with fever, recurrent urticarial rash and arthralgia of the hip joints. His clinical course was complicated by the development of an acute nephritic syndrome. Renal biopsy revealed mesangiocapillary glomerulonephritis. Complement C3 and C4 levels were markedly depressed. The patient was initially thought to have an infectious process with acute post-infectious glomerulonephritis. HUVS was established as the correct diagnosis only after a skin biopsy revealed leucocytoclastic vasculitis. HUVS should be included in the differential diagnosis of a child who presents with urticaria, arthralgia/arthritis and coexistent glomerulonephritis and/or pulmonary disease.
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