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European journal of molecular biology and biochemistry

Volume 1, Issue 5, 2014
Mcmed International
European journal of molecular biology and biochemistry
Issn
2348 - 2192 (Print), 2348 - 2206 (Online)
Frequency
bi-annual
Email
editorejmbb@mcmed.us
Journal Home page
http://mcmed.us/journal/ejmbb
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Abstract
Title
STUDY OF ABG ANALYSIS IN RELATION TO SEVERITY OF ORGANOPHOSPHORUS POISONING
Author
Maharudra Shekhanawar* and Sarala HT
Email
drmsshekh009@gmail.com
keyword
Organophosphorus Poisoning, ABG Analysis, Acidosis.
Abstract
Organophosphates exert their toxicity by interfering with acetylcholine by inhibiting acetyl cholinesterase’s enzyme and many number of enzymes belonging to the group of carboryl esterases, paraoxonases (A-esterases) and other nonspecific proteases.Normally the enzyme acetyl cholinesterase hydrolyses the acetyl choline to two inactive fragments, choline and acetic acid, preventing continued stimulation of local receptors and eventual paralysis of the nerve and muscle. A detailed clinical examination of patients was done. In patients with respiratory failure, oxygen saturation using pulse oximeter, and with arterial blood gas analysis was done. Other relevant investigations available in the infrastructure was done wherever required. Grading of severity of poisoning was done according to clinical features and peradynia organ phosphorus scale, and those who require ventilatory support and those who did not require ventilatory support were assessed. Those who required mechanical ventilatory support, were put on mechanical ventilator and data accumulated was analysed with respect to above objectives. Out of 500 cases of ABG analysis, 71 cases showed respiratory acidosis of which 32 survived & 39 expired.210 cases showed respiratory alkalosis, of which 185 patients survived & 25 expired Irrespective of level of consciousness, clinical respiratory inadequacy, if ABG shows respiratory acidosis patients needs ventilatory support.
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