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European journal of molecular biology and biochemistry

Volume 11, Issue 1, 2024
Mcmed International
European journal of molecular biology and biochemistry
Issn
2348 - 2192 (Print), 2348 - 2206 (Online)
Frequency
bi-annual
Email
editorejmbb@mcmed.us
Journal Home page
http://mcmed.us/journal/ejmbb
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Abstract
Title
PROGNOSTIC SIGNIFICANCE OF PSUEDOCHOLINESTRASE ESTIMATION AND QUANTITY OF POISON IN RELATION TO SEVERITY OF ORGANOPHOSPHORUS POISONING
Author
Maharudra Shekhanawar and Sarala HT
Email
drmshekh009@gmail.com
keyword
Organophosphorus Poisoning, Psuedocholinestrase, Acetylcholine.
Abstract
Organophosphates inhibit acetyl cholinesterase enzyme and causes accumulation of acetylcholine in myoneural junction and at synapses. Mortality ranges from 10-20%.1 Most of the deaths are due to acute respiratory failure due to central respiratory depression, respiratory muscle weakness or direct pulmonary effects. A detailed clinical examination of patients was done. In patients with respiratory failure, oxygen saturation using pulse oximeter, and with arterial blood gas analysis was done. Other relevant investigations available in the infrastructure was done wherever required. Grading of severity of poisoning was done according to clinical features and peradynia organophosphorus scale, and those who require ventilatory support and those who did not require ventilatory support were assessed Incidence of mortality was significantly associated with lower pseudocholinesterase level (P<0.001). Most of the moderate to severe degree of poisoning land up in respiratory distress where ventilator support is required which improves survival.
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