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Der Pharmacologia Sinica

Volume 1, Issue 1, 2014
Mcmed International
Der Pharmacologia Sinica
Issn
XXX-XXXX (Print), XXXX-XXXX (Online)
Frequency
bi-annual
Email
editordps@mcmed.us
Journal Home page
http://mcmed.us/journal/dps
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Abstract
Title
MULTIGENERATIONAL STUDY TO ACCESS THE MATERNOTOXICITY OF SLUDGE LEACHATE FROM TEXTILE INDUSTRIES AT PALI (INDIA) IN SWISS ALBINO MICE
Author
Himani Tiwari
Email
dr.himanitiwari@gmail.com
keyword
Leachate, Maternal Toxicity, Prepartum, Postpartum, Lacrimation.
Abstract
Water and soil pollution is inherited through the uncontrolled and indiscriminate discharge of pollutants from domestic, commercial and industrial sources into water bodies. This is visible everywhere and the water pollution problem is progressively mounting in our country. An attempt has been made to compare the maternotoxic effect of sludge leachate administered during two generations. Here the leachate obtained is from CETP, Pali which receives effluent exclusively from textile and dyeing industries located at Pali. It is diluted with water according to low level exposure dose concentration of 1/1000 and then administered to Swiss albino mice along with control group receiving simple tap water for consecutive three generations in order to access the long term effect of leachate. Research finding revealed that the treated sludge leachate from CETP, Pali at the tested dose level produced maternal toxicity to certain extent at both the generations. Maternal toxicity due to sludge leachate was evident by significant reduction in body weight gain during both prepartum and postpartum period, substantial loss of body fur and restlessness in F1 generation. No significant adverse effect was seen in first generation while no second generation was observed indicating the potential toxicity of leachate and ability to accumulate and persist inside the body. The toxic symptoms in mothers were muscular tremors, ataxia, convulsions, hyper salivation, lacrimation and restlessness.
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