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European journal of molecular biology and biochemistry

Volume 1, Issue 5, 2014
Mcmed International
European journal of molecular biology and biochemistry
Issn
2348 - 2192 (Print), 2348 - 2206 (Online)
Frequency
bi-annual
Email
editorejmbb@mcmed.us
Journal Home page
http://mcmed.us/journal/ejmbb
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Abstract
Title
ASSOCIATION OF PLASMA TUMOR NECROSIS FACTOR-ALPHA (TNF-Α) LEVELS IN PATIENTS WITH PRIMARY OPEN ANGLE GLAUCOMA
Author
Altaf A. Kondkar*
Email
akondkar@gmail.com
keyword
Inflammation, POAG, tumor necrosis factor-alpha.
Abstract
To investigate the association of plasma levels of tumor necrosis factor-alpha (TNF-α) in patients with primary open angle glaucoma (POAG) patients as compared to non-glaucomatous controls. TNF-α concentrations were measured using sandwiched enzyme-linked immunosorbent assay (ELISA) in plasma samples from 39 POAG patients and 36 controls. The assay was performed in duplicate on an automated ChemWell-T ELISA analyzer. The mean (± SD) concentration of plasma TNF-α in POAG patients (1.99 ± 2.32 pg/mL) was significantly increased (P = 0.0144) as compared to controls (0.82 ± 1.62). Similarly, the median levels were also found to be significantly different (P = 0.03). Plasma TNF-α level is significantly elevated in POAG patients as compared to non-glaucomatous control group supporting a key role of systemic TNF- α in glaucoma. The results of these findings however, need to be replicated in larger cohort in our population.
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