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International Journal of Advances In Case Reports

Volume 11, Issue 1, 2024
Mcmed International
International Journal of Advances In Case Reports
Issn
XXX-XXXX (Print), 2349 - 8005 (Online)
Frequency
bi-annual
Email
editorijacr@mcmed.us
Journal Home page
http://mcmed.us/about/ijacr
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Abstract
Title
MANAGEMENT OF GIANT CELL MALIGNANT FIBROUS HISTIOCYTOMA (MFH) OF HEAD AND NECK WITH VASCULAR RECONSTRUCTION
Author
Ashish Jakhetiya*, Vineet Goel, Palaniappan R, Devajit Nath, Sunil Kumar
Email
jakashish@gmail.com
keyword
Immunohistochemistry, Malignant fibrous histiocytoma, Sarcoma, Vascular Reconstruction.
Abstract
Giant cell rich malignant fibrous histiocytoma (MFH) is a mesenchymal tumor and accounts for 3-15% of all cases of MFH. The diagnosis is based on histology and immunohistochemistry that helps in differentiation from other fibrohistiocytic lesions. Giant cell MFH in the head and neck region is a rare entity. We report a case of 67 year old male patient with a left supraclavicular tumor invading the surrounding soft tissue and salivary gland. Radical excision of the tumor and partial excision and patch repair of subclavian vein was done. Histologically, the tumor consisted of spindle shaped cells with prominent mitoses, and abundant, osteoclast-like multinucleated giant cells. Tumor cells showed positive immunoreactivity for Vimentin and Ki-67 while negative for Cytokeratin, SMA, CD34, osteopontin, HMB 45, CD 56, myoglobin and EMA .The giant multinucleated cells were CD68 positive. Therefore the present communication provides an additional case of this rare variant of sarcoma in the head and neck region and its management.
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